Covalent cross-links in polyampholytic chitosan fibers enhances bone regeneration in a rabbit model

- Citrate-chitosan fibers with dual cross-linking (ionic as well as covalent) were prepared.
- The fibers were mechanically unique with twin property of elasticity and energy dissipation.
- Improved interfacial properties demonstrated by dual cross-linked fibers.
- Enhanced osteogenic differentiation and better osseous regeneration on the fibers.