کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
599625 1454283 2014 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Development of a folate-modified curcumin loaded micelle delivery system for cancer targeting
ترجمه فارسی عنوان
توسعه یک سیستم تحویل میسلی لود شده کورکومین برای هدف گیری سرطان
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی شیمی کلوئیدی و سطحی
چکیده انگلیسی


• The folate-modified Curcumin loaded micelles (Cur-FPPs) were prepared by thin-film hydration method.
• The Cur-FPPs increased the cytotoxicity and cellular uptake of Cur on MCF-7 and HepG2 cells in vitro.
• The Cur-FPPs prolonged the half-life of Cur in rats.

Targeted drug delivery system for tumor cells is an appealing platform on enhancing the therapeutic effects and reducing the side effects of the drug. In this study, we developed folate-modified curcumin (Cur) loaded micelles (Cur-FPPs) for cancer chemotherapy. The targeting material, Folate-PEG3000-PLA2000, was synthesized by the amide bond formation reaction. And the Cur loaded micelles were prepared by thin-film hydration method with mPEG2000-PLA2000 (Cur-PPs) or mPEG2000-PLA2000 and Folate-PEG3000-PLA2000 (Cur-FPPs) as carrier. A central composite design (CCD) was used to optimize the formulation, and the optimized Cur-FPPs was prepared with the weight ratio of Folate-PEG3000-PLA2000 and mPEG2000-PLA2000 at 1:9. The average size of the mixed micelles was 70 nm, the encapsulating efficiency and drug-loading were 80.73 ± 0.16% and 4.84 ± 0.01%, respectively. Compared with the Cur propylene glycol solution, the in vitro release of Cur from Cur-FPPs showed a sustained manner. Furthermore, the in vitro cytotoxicity and cellular uptake of Cur-FPPs were significantly enhanced towards MCF-7 and HepG2 cells. The pharmacokinetic studies in rats indicated that a 3-fold increase in the half-life was achieved for Cur loaded micelle formulations relative to solubilized Cur. All the results demonstrated that folate-modified Cur micelles could serve as a potential nanocarrier to improve the solubility and anti-cancer activity of Cur.

The Cur-FPPs’ preparing flow chart and cellular uptake on MCF-7 and HepG2 cells in vitro.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Colloids and Surfaces B: Biointerfaces - Volume 121, 1 September 2014, Pages 206–213
نویسندگان
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