Triclosan-loaded poly(amido amine) dendrimer for simultaneous treatment and remineralization of human dentine

• We have successfully prepared and characterized a group of triclosan-loaded carboxyl-terminated PAMAM dendrimers.
• The dendrimer can induce in situ remineralization on the dentine and release anti-bacterial drug for local treatment at the same time.
• The newly generated crystals are similar to the natural dentine in terms of shape, size and orientation degree.
• This system is proved to be low cytotoxicity by MTT assay.
• The drug release profiles are controlled by both dendrimer encapsulation capability and the mineralization degree.

In order to treat dental caries of damaged dentine, triclosan-loaded carboxyl-terminated poly(amido amine) dendrimer (PAMAM-COOH) is prepared and characterized. While being incubated in artificial saliva, triclosan-loaded PAMAM-COOH formulation can induce in situ remineralization of hydroxyapatite (HA) on etched dentine, and the regenerated HA has a similar crystal structure with natural dentine. It can also release the encapsulated triclosan for a long period. The interesting drug release profiles are controlled by both dendrimer encapsulation capability and the mineralization degree, which are ideal to obtain multifunctional properties of long-term release of anti-bacterial drug for local treatment during the remineralization process. The triclosan-loaded G4-COOH provides a general strategy to cure dental caries and repair damaged dentine at the same time, which forms a potential restorative material for dental repair.

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