Facile access to cytocompatible multicompartment micelles with adjustable Janus-cores from A-block-B-graft-C terpolymers prepared by combination of ROP and ATRP

- Novel poly(ɛ-caprolactone)-based terpolymers with an A-block-B-graft-C structure are proposed.
- Two consecutive controlled polymerization, ring-opening polymerization and atom transfer radical polymerization are employed to prepare the terpolymers.
- Multicompartment micelles (MCMs) with well-segregated Janus-cores are generated from the aqueous assembly of obtained terpolymers.
- The compartment balance in the core is adjustable by altering the B and C composition.
- The MCMs show excellent cytocompatibility in mouse and human cells.