Highly selective differential pulse voltammetric determination of phenazopyridine using MgCr2O4 nanoparticles decorated MWCNTs-modified glassy carbon electrode

• A modified glassy carbon electrode based on MWCNTs decorated with MgCr2O4 nanoparticles was fabricated.
• The voltammetric behavior of phenazopyridine at the modified electrode was studied.
• Different electrochemical methods and impedance spectroscopy were used for this study.
• Phenazopyridine was measured in pharmaceutical, urine and human blood serum samples.

A selective modified glassy carbon electrode based on multiwall carbon nanotubes decorated with MgCr2O4 nanoparticles was fabricated and used for the determination of phenazopyridine using differential pulse voltammetry. The electrochemical response of the modified electrode toward phenazopyridine was characterized by different electrochemical methods including differential pulse voltammetry (DPV), cyclic voltammetry (CV), and impedance spectroscopy. The prepared electrode showed an efficient synergic effect on the oxidation of phenazopyridine at pH 6.0. The oxidation peak current was proportional to the concentration of phenazopyridine from 0.05 to 7.5 μmol L−1. The detection limit was 0.025 μmol L−1. The applicability of the method was confirmed with satisfactory results obtained through the assay of phenazopyridine in human plasma, urine samples, and pharmaceuticals.

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