Methotrexate intercalated layered double hydroxides with different particle sizes: Structural study and Controlled release properties

- The particle size can be precisely controlled by hydrothermal treatment.
- Hydrothermal treatment has no effect on compositions of MTX/LDHs.
- Inversion of (0 0 3) and (0 0 6) intensity is due to π-π stacking of benzene ring.
- The particle size can greatly influence the properties of MTX/LDHs.
- Larger particles are more efficient in the suppression of the tumor cells.