کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
599919 1454287 2014 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A density gradient of basic fibroblast growth factor guides directional migration of vascular smooth muscle cells
ترجمه فارسی عنوان
شیب چگالی فاکتور رشد فیبروبلاست پایه هدایت حرکت مورب سلول های عضله صاف عروقی است
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی شیمی کلوئیدی و سطحی
چکیده انگلیسی


• A density gradient of basic fibroblast growth factor is fabricated.
• Up to 70% cells migrate unidirectionally on the bFGF gradient.
• The bFGF gradient does not influence on the cell migration rate.

The migration of vascular smooth muscle cells (VSMCs) is an important process in many physiological events. It is of paramount importance to control the migration rate and direction of VSMCs by biomaterials. In this paper, a density gradient of basic fibroblast growth factor (bFGF) was fabricated using an injection method and the bio-conjugation between heparin and bFGF. The density of bFGF gradually increased with a slope of 17 ng/cm2/mm. Adhesion and migration of VSMCs were studied on the bFGF gradient. The VSMCs exhibited preferential orientation and an enhanced directional migration behavior on the gradient surface. Up to 70% cells migrated towards the region with a higher density of bFGF on the gradient. However, the bFGF gradient had no effect on the cell migration rate.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Colloids and Surfaces B: Biointerfaces - Volume 117, 1 May 2014, Pages 290–295
نویسندگان
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