Micellar nanoparticles loaded with gemcitabine and doxorubicin showed synergistic effect

- Gemcitabine and doxorubicin were separately conjugated to biodegradable polyesters.
- The two drug conjugates can be mixed at desirable ratio and self-assembled into micelles M(Gem/Dox) with both gemcitabine and doxorubicin.
- M(Gem/Dox) displayed controlled drug release and synergism in vitro.