Conformational changes in human plasma proteins induced by metal oxide nanoparticles

- Metal oxide nanoparticles induce conformational changes in some human plasma protein fractions determined by fluorescence spectroscopy.
- ZnO Nps induce a decrease in the thermal stability of albumin and fibrinogen, and interfere with the function of fibrinogen in the clotting assay.
- A conversion of α-helix to β-sheet structure in the secondary structure of albumin is seen by FTIR spectroscopy.
- The interaction with albumin is pH-dependent, as it is inhibited at acidic pH.