Effect of extremes of body weight on drug level in patient treated with standard dose of rivaroxaban for venous thromboembolism; real life experience

- Patients with extremes of body weight (EBW) are underrepresented in clinical trials.
- Effect of EBW on the drug level with standard dose of rivaroxaban was assessed.
- Rivaroxaban levels were significantly higher in patients of weight < 50 kg than others.
- Bleeding & recurrent VTE rates were not associated with drug levels or body weight.