Isoniazid loaded core shell nanoparticles derived from PLGA-PEG-PLGA tri-block copolymers: In vitro and in vivo drug release

► Low molecular weight PLGA-PEG-PLGA triblock copolymers are obtained in solid form. ► First time, Isoniazid loaded polymeric core-shell nanoparticles are reported. ► In vitro release kinetics mechanisms are investigated. ► The in vitro and in vivo drug release characteristics are reported. ► The nanoparticles showed a sustained and mechanistic drug release up to 124 h.