کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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6000448 | 1579202 | 2016 | 5 صفحه PDF | دانلود رایگان |
BackgroundTranexamic acid can be effective at decreasing blood loss and transfusion requirements associated with total hip arthroplasty (THA), but few studies have compared the efficacy of different intravenous dosing regimes. This double-blind, randomized controlled trial compared the ability of two doses of intravenous TXA (IV-TXA, 10 or 15Â mg/kg) to reduce bleeding and transfusions associated with THA.Materials and methodsA total of 124 patients scheduled for THA were consecutively randomized 1:1:1 into three parallel arms: control (placebo), 10Â mg/kg IV-TXA and 15Â mg/kg IV-TXA.ResultsThe proportion of patients who experienced bleeding and required transfusions was significantly lower in the 15Â mg/kg IV-TXA group (1 of 42, 2.4%) than in the 10Â mg/kg IV-TXA group (8 of 39, 20.5%; PÂ =Â 0.012) and in the control group (10 of 38, 26.3%; PÂ =Â 0.002). In fact, this proportion was similar between the 10Â mg/kg IV-TXA and control groups (PÂ =Â 0.547). Ultrasound examination on postoperative day 3 revealed only one case of asymptomatic deep vein thrombosis (in the femoral vein) in the 10Â mg/kg IV-TXA group, which was managed by administering low-molecular-weight heparin. No cases of deep-vein thrombosis were observed in the other two groups. No cases of symptomatic pulmonary embolism were observed.ConclusionIV-TXA at 10Â mg/kg significantly reduced blood loss and mitigated the decrease in hemoglobin and hematocrit after THA, but it did not significantly reduce the need for transfusions. In contrast, a dose of 15Â mg/kg reduced both bleeding and transfusion requirements. Our results argue for a dose of 15Â mg/kg when using single-dose IV-TXA.Level of evidenceTherapeutic Level I
Journal: Thrombosis Research - Volume 141, May 2016, Pages 119-123