کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6000559 1579203 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Hemostatic alterations during coronary artery bypass grafting
ترجمه فارسی عنوان
تغییرات هماتوستیک در طی پیوند عروق کرونر قلب
کلمات کلیدی
خونریزی، کنترل خونریزی، انعقاد خون، دوران قلب و عروق، جراحی، عوارض،
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی


- No evident platelet activation, dysfunction or consumption was seen in CABG surgery.
- Only minor and transient fibrinolysis was observed under tranexamic acid use.
- The most prominent factor impairing hemostasis after CABG surgery is hemodilution.
- A hypercoagulable state was seen on the fifth postoperative day in all patients.

IntroductionThe origination of blood loss after cardiac surgery is not fully explained, but is related to operation trauma and use of cardiopulmonary bypass (CPB). However, the extent of their contribution is incompletely known and might differ between distinct operation procedures.Materials and methodsThree groups of CABG procedures were studied: 1) off-pump coronary artery bypass surgery (OPCAB, n = 11) without CPB, 2) CABG with use of CPB (CABG, n = 11) and 3) CABG with use of CPB combined with aortic valve replacement (AVR, n = 11). Activation of coagulation and fibrinolysis was measured at various time points by flow cytometry, platelet aggregometry, thrombelastography, the Nijmegen Hemostasis Assay, prothrombin fragment 1 + 2 and tissue plasminogen activator.Results and conclusionsThe use of CPB during cardiac surgery decreased platelet counts, clot strength, fibrinogen, hematocrit and albumin concentrations during the procedure. No perioperative platelet activation was observed and functional (collagen induced) platelet aggregation was transiently impaired, but recovered after surgery in all groups. Patients operated with use of CPB showed increased tissue plasminogen activator concentrations after reperfusion followed by minor and transient fibrinolysis. After all types of surgery coagulation parameters and platelet aggregation showed a rebound above preoperative levels. To conclude, no evident platelet activation, dysfunction or consumption was demonstrated. In patients using tranexamic acid the most prominent factor impairing hemostasis after CABG surgery was hemodilution associated with CPB.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Thrombosis Research - Volume 140, April 2016, Pages 140-146
نویسندگان
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