کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6000760 1182937 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Topical use of antithrombotics: Review of literature
ترجمه فارسی عنوان
استفاده موضعی از آنتی ترومبوتیک: مرور ادبیات
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی


- There is a growing trend of administering antithrombotics topically.
- We review the available literature regarding topical use of antithrombotics.
- Topical antithrombotics are administered in a large variety of clinical settings.
- The most commonly used topical antithrombotic is heparin.
- Guidelines are needed to standardize this treatment and improve patient outcomes.

While antithrombotics are usually administered intravenously, subcutaneously or orally, there are a number of publications reporting topical application of anticoagulation therapy. This paper aims to review the available literature regarding clinical conditions, the details of the topical antithrombotic treatment, as well as positive or adverse effects in an attempt to ascertain the safety and efficacy of this form of treatment. Published literature was searched to identify publications reporting the use of antithrombotic treatments administered via topical application between 1st January1990 and 1st January 2013. There were 43 studies reported in 10 different clinical conditions. Majority of the studies were randomized controlled trials (51.2%), prospective studies (18.6%) or case reports (11.6%). The clinical conditions in which topical antithrombotics were administered included: microangiopathy, acute haemorrhoids, periodontitis, dermatitis, burns, ocular conditions and surgery, blunt force impact, scars, as well as clinical conditions associated with superficial venous thrombosis (SVT). The most commonly used topical antithrombotic was heparin (79.1% of studies). The respective dosage of different antithrombotics varied depending on specific clinical conditions. While most studies reported mean improvements or resolution of symptoms/condition in patients, the patient outcomes were variable. This review demonstrates that topical antithrombotic treatment is used according to a wide variety of protocols, with a subsequent variability in patient outcomes. Specific guidelines for the use of topical antithrombotics should be developed to standardize this form of treatment and ensure the best possible outcomes for patients.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Thrombosis Research - Volume 135, Issue 4, April 2015, Pages 575-581
نویسندگان
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