کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
600107 1454295 2013 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Trans-ferulic acid-based solid lipid nanoparticles and their antioxidant effect in rat brain microsomes
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی شیمی کلوئیدی و سطحی
پیش نمایش صفحه اول مقاله
Trans-ferulic acid-based solid lipid nanoparticles and their antioxidant effect in rat brain microsomes
چکیده انگلیسی


• SLN-FA and SLN-SF-FA were prepared and characterized.
• Both SLNs dose-dependently reduced lipid peroxidation induced by NADPH/ADP-Fe3+ and SIN-1.
• SLN-SF-FA displayed greater efficacy and potency against AAPH- and NADPH/ADP-Fe3+-induced lipid peroxidation.
• The SLNs could prevent the FA degradation making it almost entirely available to explicate its antioxidant activity.

In this study, stearic acid- and stearyl ferulate-based solid lipid nanoparticles containing trans-ferulic acid (SLN-FA and SLN-SF-FA, respectively), were prepared and characterized for loading efficiency, size and shape. In addition, by using rat brain microsomes, we evaluated in vitro the antioxidant activity of these formulations against three well known initiators of lipid peroxidation, such as AAPH, NADPH/ADP-Fe3+ and SIN-1 which in turn generate the peroxyl and perferryl radicals as well as peroxynitrite, respectively. Commercially available FA and its ethyl ester (FAEE) were used as comparators. Both SLN-FA and SLN-SF-FA dose-dependently reduced lipid peroxidation induced by the three oxidants. Interestingly, SLN-SF-FA displayed greater efficacy (EC50) and potency (maximal activity) against AAPH- and NADPH/ADP-Fe3+-induced lipid peroxidation. Our results support the idea that this new formulations could facilitate the uptake of FA by the cells because of their lipophilic structure, thus increasing FA bioavailability. Furthermore, stearyl ferulate-based nanoparticles could prevent the degradation of FA entrapped on their structure, making FA almost entirely available to explicate its antioxidant power once released

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Colloids and Surfaces B: Biointerfaces - Volume 109, 1 September 2013, Pages 273–279
نویسندگان
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