کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6001703 | 1182956 | 2014 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Lupus anticoagulant and thrombosis in splenic marginal zone lymphoma Lupus anticoagulant and thrombosis in splenic marginal zone lymphoma](/preview/png/6001703.png)
- There is a high prevalence (13%) of lupus anticoagulant (LA) in patients with SMZL.
- Lupus anticoagulant is associated with thrombosis, especially after splenectomy.
- LA negativity occurred after immuno-chemotherapy, not splenectomy.
- FXII deficiency and Protein S deficiency were commonly associated with LA.
IntroductionSplenic marginal zone lymphoma (SMZL) is a rare low-malignant Non-Hodgkin lymphoma (NHL), in which immune mediated paraneoplastic phenomena such as autoimmune hemolytic anemia (AIHA), autoimmune thrombocytopenia (ITP) and C1 esterase inhibitor deficiency are relatively common.Materials and MethodsWe performed a multicenter retrospective study in 70 patients on the prevalence and clinical features of antiphospholipid antibodies (aPLA) in SMZL.Results and ConclusionsNine patients (13%) had the diagnosis of a lupus anticoagulant (LA). The occurrence of venous thromboembolic events was significantly higher in LA positive patients compared to LA negative patients (4/9 [44%] vs 5/61 [8%], p = 0.002), especially within 12 months after splenectomy (3/6 [50%] vs 2/28 [7%], p = 0.007). None of the patients with LA had a persistent complete remission of LA after splenectomy, but complete remission of LA was achieved in 2/2 patients after rituximab-bendamustine immuno-chemotherapy. In conclusion, our data show a relatively high prevalence of aPLA in SMZL and an increased risk of postsplenectomy thrombosis in these patients. The fact that rituximab-bendamustine was effective for eradicating LA may be considered as an argument for using immuno-chemotherapy as first line therapy in SMZL patients with LA.
Journal: Thrombosis Research - Volume 134, Issue 5, November 2014, Pages 980-984