کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
600367 | 1454301 | 2013 | 6 صفحه PDF | دانلود رایگان |
Literature reports provide evidence that nanomolar concentrations of spaghetti-like, high molecular weight polymers decrease the hydrodynamic resistance of blood thereby improving impaired blood circulation. It has been suggested that the polymer-induced drag reduction is caused by the corralling of red blood cells (RBCs) among extended macromolecules aligned in the flow direction. This mechanism predicts that drag-reducing polymers must affect the conductivity of completely dispersed blood, time-dependent and steady state structural organization of aggregated RBCs at rest. However, experimental results obtained at the concentration of poly(ethylene oxide) (PEO, MW = 4 × 106) of 35 ppm show that neither the conductivity of completely dispersed blood, nor the kinetics of RBC aggregation occurring after the stoppage of flow, nor the structural organization of aggregated RBCs in the quiescent blood are affected by PEO. As these results are at odds with the “corralling” hypothesis, it is assumed that the effect of these polymers on the drag is associated with their interactions with local irregularities of disturbed laminar blood flow.
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► Corralling of erythrocytes by polymer molecules was supposed to decrease the drag.
► If so, polymers must affect the structural organization of erythrocytes.
► In conflict with this prediction, experimental results do not reveal this effect.
► Interactions of polymers with local irregularities of blood flow reduce the drag.
Journal: Colloids and Surfaces B: Biointerfaces - Volume 103, 1 March 2013, Pages 354–359