Poloxamine micellar solubilization of α-tocopherol for topical ocular treatment

► α-Tocopherol interaction with poloxamines at the air-water interface raises with temperature. ► Apparent solubility of α-tocopherol increases 6000-fold in 20% T1107 at 25 °C. ► Polymeric micelles provide sustained release of α-tocopherol in 0.9% NaCl. ► Micellar systems were physically and chemically stable for 3 months at 4 °C.