کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6003947 1579526 2015 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Implications of diet modification on sympathoinhibitory mechanisms and hypertension in obesity
ترجمه فارسی عنوان
پیامدهای تغییر رژیم غذایی بر مکانیسم های سمپاتوئیدی و فشار خون بالا در چاقی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
چکیده انگلیسی


- OP animals had a greater weight gain than OR/controls despite being on a low-fat diet.
- Despite no weight loss on a low-fat diet, OP animals were not hypertensive.
- Sympathoinhibitory responses to gut hormones were restored in OP animals.
- Diet modification can restore normotension without the need for weight reduction.

We have previously demonstrated that a number of rats fed a moderately high-fat diet (MHFD) become obese and hypertensive and had compromised sympathoinhibitory and vasodilator responses to the gut hormones cholecystokinin (CCK) and gastric leptin. This has implications for increased resistance in vascular beds that attract a large proportion of cardiac output after a meal and may be an important mechanism underlying the development of hypertension in obesity in which food consumption is greatly increased. The aim of this study was to determine whether swapping a MHFD for a low-fat diet (LFD) would induce weight loss in obese animals, reverse the signs of hypertension and restore sympathoinhibitory reflexes. Male Sprague-Dawley rats were placed on a LFD (controls; n = 8) or a MHFD (n = 24) for 11 weeks after which the latter displayed either an obesity-prone (OP) or obesity-resistant (OR) phenotype. All animals were fed a LFD for a further 6 weeks after which they were anaesthetised with isoflurane and artificially ventilated for evaluation of resting arterial pressure (AP) and renal sympathetic nerve responses to CCK (0.1-4 μg/kg) and leptin (15 μg/kg). Weight gain in OP animals remained higher than OR or controls following diet switch (P < 0.05 for both). Resting AP was not significantly different between OP (103 ± 4 mmHg), OR (102 ± 3 mmHg) or control (104 ± 3 mmHg) animals and sympathoinhibitory responses to CCK or leptin were not different between the groups (P > 0.05). These results demonstrate that diet modification can have beneficial effects on sympathetic function and restore normotension without the need for weight reduction.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Autonomic Neuroscience - Volume 189, May 2015, Pages 25-30
نویسندگان
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