کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6003971 1579528 2015 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Nitric oxide bioavailability affects cardiovascular regulation dependent on cardiac nerve status
ترجمه فارسی عنوان
بیوپلاسمیت اکسید نیتروژن بر تنظیم قلب و عروق وابسته به وضعیت عصب قلب تاثیر می گذارد
کلمات کلیدی
نورونهای قلب درونی، اهدا کننده اکسید نیتریک، ایزوفرمهای سنتاز اکسید نیتریک، جریان خون میوکارد، ناتوانی حاد قلبی،
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
چکیده انگلیسی


- NO donor administered to a ganglionated plexus modulates coronary blood flow
- Cardiac decentralization affects myocardial blood flow distribution
- Subepicardial blood flow is reduced after cardiac decentralization

The sympathetic nervous system and nitric oxide (NO) contribute to regulation of vascular tone, blood flow regulation and cardiac function. Intrinsic cardiac neurons are tonically influenced by locally released NO and exogenous NO donors; however, the role of intact central neural connections remains controversial. We investigated the effects of S-nitroso-N-acetylpenicillamine (SNAP) administered into an intracoronary artery near the ventral interventricular ganglionated plexus (VIVGP) to evaluate distribution of myocardial blood flow (MBF) and ventricular function in normal and acute cardiac decentralized dogs. MBF was measured with microspheres during infusion of SNAP (100 μM, IC) after systemic administration of 7-nitroindazole (nNOS blocker) followed by Nω-nitro-L-arginine methyl ester (LN; non-selective NOS blocker). Cardiac dynamics were not significantly affected by cardiac decentralization; several of these parameters (aortic systolic and diastolic pressures) were significantly increased after systemic administration of LN. Overall SNAP administered to the VIVGP increased blood flow in the anterior LV wall (vs. posterior LV wall) without affecting other cardiodynamic factors. In cardiac decentralized dogs subepicardial blood flow to the anterior LV wall during LN + SNAP was diminished resulting in a significantly higher inner:outer blood flow ratio (index of blood flow uniformity across the LV wall). LV function was not affected by acute cardiac decentralization; however, LV ejection fraction decreased markedly after LN (reduced NO bioavailability). These results validate earlier claims that reduced NO bioavailability imposes an upper limit on myocardial blood flow regulation and its transmural distribution. These effects are exacerbated after disconnection of intrinsic cardiac neurons from intact central neuron connections.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Autonomic Neuroscience - Volume 187, January 2015, Pages 70-75
نویسندگان
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