کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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6004216 | 1184231 | 2013 | 7 صفحه PDF | دانلود رایگان |

The objective of this study was to explore the influence of the renin-angiotensin system on cardiac prooxidants and antioxidants levels and its association to autonomic imbalance induced by hyperthyroidism. Male Wistar rats were divided into four groups: control, losartan (10Â mg/kg/day by gavage, 28Â day), thyroxine (T4) (12Â mg/L in drinking water for 28Â days), and T4Â +Â losartan. Spectral analysis (autonomic balance), angiotensin II receptor (AT1R), NADPH oxidase, Nrf2 and heme-oxygenase-1 (HO-1) myocardial protein expression, and hydrogen peroxide (H2O2) concentration were quantified. Autonomic imbalance induced by hyperthyroidism (~Â 770%) was attenuated in the T4Â +Â losartan group (~Â 32%) (PÂ <Â 0.05). AT1R, NADPH oxidase, H2O2, as well as concentration, Nrf2 and HO-1 protein expression were elevated (~Â 172%, 43%, 40%, 133%, and 154%, respectively) in T4 group (PÂ <Â 0.05). H2O2 and HO-1 levels were returned to control values in the T4Â +Â losartan group (PÂ <Â 0.05). The overall results demonstrate a positive impact of RAS blockade in the autonomic control of heart rate, which was associated with an attenuation of H2O2 levels, as well as with a reduced counter-regulatory response of HO-1 in experimental hyperthyroidism.
Journal: Autonomic Neuroscience - Volume 177, Issue 2, October 2013, Pages 163-169