کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6004236 1184231 2013 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Does exposure to chronic stress influence blood pressure in rats?
ترجمه فارسی عنوان
آیا قرار گرفتن در معرض تنش مزمن فشار خون را در موش ها تاثیر می گذارد؟
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
چکیده انگلیسی

The principal aim of this study was to determine whether prolonged chronic footshock stress can evoke sustained changes in blood pressure in rats and to elucidate possible underlying neurochemical mechanisms as mediated by the sympathoadrenal system. Adult male Wistar rats instrumented for telemetric recording of arterial pressure, heart rate and locomotor activity were subjected to six weeks of inescapable unpredictable electrical footshocks (FS +) or were exposed to shock chambers but were not shocked (FS −). Compared to FS − animals, FS + animals had significantly reduced body weight gain (by 30%), locomotor activity (by 25%) and social interaction time (by 30%) - symptoms commonly induced by chronic stress and depression in humans. These changes were associated with small, but significant increases in systolic blood pressure (by 7%) and pulse pressure (by 11%) in FS + rats relative to FS − rats. We have also found neurochemical alterations in sympathoadrenal pathways (that lasted for at least one week post-stress) including about 2-3 fold increases in the levels of tyrosine hydroxylase phosphorylation in the sympathetic ganglia and adrenal gland and a 1.8-fold increase in the expression of the Angiotensin II receptor type 1 protein in the adrenal gland of FS + rats relative to FS − rats. We conclude that uncontrollable and unpredictable footshock stress can lead to elevation in systolic blood pressure when applied for an extended period of time (six weeks) in Wistar rats, and that these changes could be mediated by stress-induced modifications in sympathoadrenal pathways.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Autonomic Neuroscience - Volume 177, Issue 2, October 2013, Pages 217-223
نویسندگان
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