کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
600434 1454303 2013 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The microstructure of collagen type I gel cross-linked with gold nanoparticles
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی شیمی کلوئیدی و سطحی
پیش نمایش صفحه اول مقاله
The microstructure of collagen type I gel cross-linked with gold nanoparticles
چکیده انگلیسی

Scanning electron microscopy, transmission electron microscopy, rheometry, and electrochemistry were used to provide insight into the microstructure of collagen type I gel (1%, w/v) modified with the tiopronin-protected (N-(2-mercaptopropionyl)glycine) gold nanoparticles (TPAu), a multivalent crosslinker. The cross-linking reaction, performed via EDC (1-ethyl-3-(3-dimethyl aminopropyl) carbodiimide) coupling, results in compliant, mechanically stable and continuous gels. The gels contain unusual interconnected collagen-TPAu particles. Electrochemical measurements of 4-hydroxy-(2,2,6,6-tetramethylpiperidine-1-oxyl) (4HT) diffusion within the gel reveal that the gel hindrance is nearly independent of the TPAu concentration. The properties of the collagen-TPAu gel make it suitable for potential biomedical applications, such as delivery of small molecule drugs.

. SEM and TEM images of collagen gel modified with gold nanoparticles.Figure optionsDownload as PowerPoint slideHighlights
► Collagen gels cross-linked with Au-nanoparticles were synthesized and characterized.
► The gels contain unusual morphology: interconnected collagen-Au-nanoparticle particles (150–400 nm).
► The gels are compliant, mechanically stable, and continuous.
► Electrochemical measurements show the gel hindrance nearly independent of the Au-nanoparticle concentration.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Colloids and Surfaces B: Biointerfaces - Volume 101, 1 January 2013, Pages 118–125
نویسندگان
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