کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
600434 | 1454303 | 2013 | 8 صفحه PDF | دانلود رایگان |
Scanning electron microscopy, transmission electron microscopy, rheometry, and electrochemistry were used to provide insight into the microstructure of collagen type I gel (1%, w/v) modified with the tiopronin-protected (N-(2-mercaptopropionyl)glycine) gold nanoparticles (TPAu), a multivalent crosslinker. The cross-linking reaction, performed via EDC (1-ethyl-3-(3-dimethyl aminopropyl) carbodiimide) coupling, results in compliant, mechanically stable and continuous gels. The gels contain unusual interconnected collagen-TPAu particles. Electrochemical measurements of 4-hydroxy-(2,2,6,6-tetramethylpiperidine-1-oxyl) (4HT) diffusion within the gel reveal that the gel hindrance is nearly independent of the TPAu concentration. The properties of the collagen-TPAu gel make it suitable for potential biomedical applications, such as delivery of small molecule drugs.
. SEM and TEM images of collagen gel modified with gold nanoparticles.Figure optionsDownload as PowerPoint slideHighlights
► Collagen gels cross-linked with Au-nanoparticles were synthesized and characterized.
► The gels contain unusual morphology: interconnected collagen-Au-nanoparticle particles (150–400 nm).
► The gels are compliant, mechanically stable, and continuous.
► Electrochemical measurements show the gel hindrance nearly independent of the Au-nanoparticle concentration.
Journal: Colloids and Surfaces B: Biointerfaces - Volume 101, 1 January 2013, Pages 118–125