کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6004784 1579561 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A novel gel based vehicle for the delivery of acetylcholine in quantitative sudomotor axon reflex testing
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
A novel gel based vehicle for the delivery of acetylcholine in quantitative sudomotor axon reflex testing
چکیده انگلیسی

This study describes a novel gel based vehicle for the delivery of acetylcholine (ACh) during quantitative sudomotor axon reflex testing (QSART). A dose and current response study were undertaken on 20 healthy control participants to characterize the efficiency of a gel based vehicle for the delivery of ACh. Values obtained for total sweat volume and latency to sweat onset with gel iontophoresis of ACh during QSART were comparable to previously published normative data using solution based vehicles. Patient discomfort, utilizing the gel based vehicle during the QSART procedure, was minimal. Improvement in iontophoresis using the gel formulation as a vehicle for ACh delivery has the potential to lower the voltage required to overcome skin resistance during QSART and may result in improved patient comfort during the procedure.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Autonomic Neuroscience - Volume 150, Issues 1–2, 5 October 2009, Pages 127-130
نویسندگان
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