Development and optimization of multiparticulate drug delivery system of alfuzosin hydrochloride

► Development of multiparticulate floating delivery system of alfuzosin hydrochloride. ► Pellets are coated with effervescent layer and Kollicoat® SR 30D. ► Pellets are based on gas generation to prolong the gastric residence time. ► The system could maintain the floating over a period of 10 h.