Nonenzymatic glucose sensor based on nickel(II)oxide/ordered mesoporous carbon modified glassy carbon electrode

A highly sensitive and selective nonenzymatic glucose sensor based on electrodepositing NiO nanoparticles on ordered mesoporous carbon (named as NiO/OMC) modified glassy carbon electrode (GCE) was constructed. The synthesized OMC was characterized by X-ray diffraction, and the morphology images of OMC nanoparticle and NiO/OMC nanocomposite were characterized by scanning electron microscope. Electrochemical behaviors of glucose at the NiO/OMC/GCE were investigated by cyclic voltammetry and amperometry, and the modified electrode showed excellent electrochemical activity toward the oxidation of glucose. At the optimum conditions, the calibration curve for glucose determination was linear in the range of 2–1000 μM with a fast response time (<2 s), and a high sensitivity of 834.8 μA mM−1 cm−2 and a low detection limit (S/N = 3) of 0.65 μM were obtained. In addition, the proposed sensor was successfully applied to analyze glucose level in human blood serum samples.

A novel NiO/OMC composite was fabricated for the nonenzymatic glucose sensing, and the proposed sensor was successfully applied to analyze glucose level in human blood serum samples.Figure optionsDownload as PowerPoint slideHighlights
► A novel nonenzymatic glucose electrochemical sensor was proposed.
► The sensor was based on nickel(II)oxide/ordered mesoporous carbon modified glassy carbon electrode.
► The developed sensor exhibited wide linear range and high sensitivity.
► The as-made sensor was also successfully applied to determine glucose content in clinic serum sample.