کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6006256 1184678 2014 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Transcranial Magnetic Stimulation (TMS)Short CommunicationTargeting of White Matter Tracts with Transcranial Magnetic Stimulation
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
Transcranial Magnetic Stimulation (TMS)Short CommunicationTargeting of White Matter Tracts with Transcranial Magnetic Stimulation
چکیده انگلیسی

BackgroundTMS activations of white matter depend not only on the distance from the coil, but also on the orientation of the axons relative to the TMS-induced electric field, and especially on axonal bends that create strong local field gradient maxima. Therefore, tractography contains potentially useful information for TMS targeting.Objective/methodsHere, we utilized 1-mm resolution diffusion and structural T1-weighted MRI to construct large-scale tractography models, and localized TMS white matter activations in motor cortex using electromagnetic forward modeling in a boundary element model (BEM).ResultsAs expected, in sulcal walls, pyramidal cell axonal bends created preferred sites of activation that were not found in gyral crowns. The model agreed with the well-known coil orientation sensitivity of motor cortex, and also suggested unexpected activation distributions emerging from the E-field and tract configurations. We further propose a novel method for computing the optimal coil location and orientation to maximally stimulate a pre-determined axonal bundle.ConclusionsDiffusion MRI tractography with electromagnetic modeling may improve spatial specificity and efficacy of TMS.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Stimulation - Volume 7, Issue 1, January–February 2014, Pages 80-84
نویسندگان
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