کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
600656 1454312 2012 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Non-specific internalization of laser ablated pure gold nanoparticles in pancreatic tumor cell
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی شیمی کلوئیدی و سطحی
پیش نمایش صفحه اول مقاله
Non-specific internalization of laser ablated pure gold nanoparticles in pancreatic tumor cell
چکیده انگلیسی

We investigate the intracellular uptake of 7.3 nm, 21.2 nm and 31.3 nm average size pure colloidal gold nanoparticles synthesized using femtosecond laser ablation technique in pure water. Dark-field imaging, transmission electron microscopy (TEM) and scanning electron microscopy (SEM) was used to assess the uptake of these pure gold nanoparticles in the pancreatic tumor cell line. We show that these ligand-free gold nanoparticles are non-toxic to these cells. The nanoparticles and cell images indicated that unmodified gold nanoparticles interacted with the cells, despite negative surface charge on both the cells and the nanoparticles. We also demonstrate that the uptake of the gold nanoparticles is size-dependent.

Figure optionsDownload as PowerPoint slideHighlights
► Generation of gold nanoparticles in pure water using pulsed laser.
► Transmission electron microscopy of gold nanoparticles.
► Gold nanoparticles internalized in tumor cell.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Colloids and Surfaces B: Biointerfaces - Volume 92, 1 April 2012, Pages 190–195
نویسندگان
, , , ,