In vitro application of paclitaxel loaded magnetoliposomes for combined chemotherapy and hyperthermia

► Magnetoliposomes of DPPC and PG, mimicking pulmonary surfactant were reported. ► Encapsulation efficiency of 8 nm sized Fe3O4 nanoparticles in liposomes was 75 ± 5%. ► Paclitaxel was coencapsulated with a high encapsulation efficiency of 83 ± 3%. ► Paclitaxel release was enhanced by 46 fold at 43 °C in comparison to 37 °C. ► Synergistic effects of hyperthermia and chemotherapy were observed.