Design and evaluation of polymer coated carvedilol loaded solid lipid nanoparticles to improve the oral bioavailability: A novel strategy to avoid intraduodenal administration

► We designed MCC-coated carvedilol loaded SLN to protect SLN from gastric milieu. ► Improved bioavailability with MCC coated-SLN (oral) compared to uncoated SLN (oral). ► No difference in bioavailability between MCC-SLN (oral) and uncoated SLN (duodenal). ► Clinically inappropriate duodenal administration can be avoided with MCC-SLN (oral).