Efficacy and time course of paired associative stimulation in cortical plasticity: Implications for neuropsychiatry

- Magnitude and time course of one hundred and four paired associative stimulation (PAS) experiments were quantitatively reviewed.
- PAS with interstimulus intervals of ±25 ms potentiates the cortex up to ninety minutes, whereas PAS with interstimulus intervals of ±10 ms depresses the cortex up to one hundred and twenty minutes.
- Results offer normative data for future PAS studies on normal and abnormal cortical plasticity.

ObjectivePaired associative stimulation (PAS) has been used to study normal and abnormal cortical plasticity. However, a normative review of PAS effects has not been provided so far. To this end, the magnitude and time course of PAS protocols was systematically evaluated here.MethodsA literature search in PubMed using the search term paired associative stimulation was conducted. Main inclusion criteria were that experiments were conducted in primary motor cortex of healthy volunteers without motor training before intervention and motor evoked potentials as primary outcome measure. This search yielded in total 104 experiments, which were analyzed to examine the potentiating (PASLTP) and depressing effects of PAS (PASLTD) on cortical excitability levels in healthy volunteers.ResultsPASLTP induces reliable and stable potentiating effects (maximum ± standard error 38.5 ± 3.3%) on cortical excitability levels up to 90 min. PASLTP was most effective when applied at frequencies of 0.05 and 0.2 Hz. Analyses of the PASLTD studies demonstrated reliable and stable depression of cortical excitability levels up to 120 min (maximum ± standard error −23.0 ± 1.9%)ConclusionsPAS significantly modulates cortical excitability. The potentiating effects of PASLTP are stronger than the depressing effects for PASLTD.SignificancePresent findings offer normative insights into the magnitude and time course of PASLTP and PASLTD-induced changes in cortical excitability levels.