Preparation and biocompatibility of nanohybrid scaffolds by in situ homogeneous formation of nano hydroxyapatite from biopolymer polyelectrolyte complex for bone repair applications

► The polyelectrolyte's functional groups regulated the crystallization process of HAP. ► A nanoscale architecture was achieved by nano distribution in porous polyelectrolyte matrix. ► In vitro test from human bone mesenchymal stem cells culture revealed good biocompatibility of the scaffold.