Polymeric emulsion and crosslink-mediated synthesis of super-stable nanoparticles as sustained-release anti-tuberculosis drug carriers

► Emulsion-solvent-surfactant-evaporation and emulsion-solvent-evaporation approaches. ► The reverse-emulsion-cationic-gelification (RECG) approach. ► The reverse-emulsion-surfactant-cationic-gelification (RESCG) approach. ► Quantitative/qualitative analysis of size, zeta potential, and polydispersity index. ► Molecular mechanics energy relationships (MMER).