Photochemically triggered reaction of glucose oxidase in a fused vesicle containing Malachite Green leuconitrile derivative

Glucose oxidase (GOD) was encapsulated in vesicles containing a photoionizable Malachite Green leuconitrile derivative (MGL). Subsequent UV irradiation of MGL afforded the fusion of GOD- and glucose-encapsulating vesicles and thus decreased the concentration of glucose in the vesicles. The time dependence of the vesicle fusion was studied using fluorescent probe molecules. This phototriggered fusion could be instrumental in the development of a system for the production of nanometer-sized bioreactors.

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► Vesicle fusion is promoted by a photoresponsive Malachite Green derivative.
► Glucose oxidase and its substrate are separately encapsulated by the vesicles.
► Irradiation triggers the reaction of glucose oxidase in the fused vesicles.