Preparation of thermoresponsive and pH-sensitivity polymer magnetic hydrogel nanospheres as anticancer drug carriers

In this work, a novel thermo and pH responsive magnetic hydrogel nanosphere poly(N-isopropylacrylamide-co-acrylic acid)/Fe3O4 (poly(NIPAAm-co-AA)/Fe3O4) has been successfully prepared. The magnetic hydrogel nanospheres with thermo and pH-sensitivity were characterized by transmission electron microscopy (TEM), dynamic light scattering (DLS), Fourier transform infrared-spectrometer (FT-IR), UV–vis absorption spectroscopy, and vibrating sample magnetometer (VSM). The magnetic hydrogel nanospheres exhibited uniform sphere structures and superparamagnetic property. Finally, the drug loading capacities and the releasing behavior of the magnetic hydrogel nanospheres were investigated with doxorubicin hydrochloride (DOX) as an anticancer drug model. The resulting magnetic hydrogel nanospheres exhibited high encapsulation efficiency (95%) to DOX under an appropriate condition. In vitro release experiments revealed that release was faster at pH 5.3 (37 °C) than at pH 7.4 (25 °C) or pH 7.4 (37 °C). The DOX-loaded magnetic hydrogel nanospheres also showed enhanced anticancer effect compared with the free drug in vitro. These presented results suggested that the magnetic hydrogel nanospheres have a potential as tumor targeting drug carrier.

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► Novel thermoresponsive and pH-sensitivity polymer magnetic hydrogel nanospheres (poly (NIPAAm-co-AA)/Fe3O4) were prepared.
► The resulting magnetic hydrogel nanospheres exhibited high encapsulation efficiency to doxorubicin hydrochloride (DOX).
► In vitro release experiments revealed that the release of DOX-loaded magnetic hydrogel nanospheres was faster at pH 5.3 (37 oC) than at pH 7.4 (25 oC) or pH 7.4 (37 oC).
► DOX-loaded magnetic hydrogel nanospheres showed enhanced anti-tumor effect compared with the free drug in vitro.