Characterization and biocompatibility of chitosan nanocomposites

► NPs in chitosan did not aggregate until higher concentrations (120-240 ppm). ► Nanocrystalline domains on chitosan surface were more evident upon addition of AuNPs (60 ppm) or AgNPs (120 ppm). ► Chitosan-Ag nanocomposites had antibacterial ability. ► Chitosan-Au promoted the repair of skin wound and hemostasis of severed hepatic portal vein.