Dual-functional composite with anticoagulant and antibacterial properties based on heparinized silk fibroin and chitosan

► A new material of the heparinized silk fibroin was synthesized by covalent grafting method. ► The first study to synthesize the dual-functional composite with anticoagulant and antibacterial properties. ► Integrated evaluation of hemolytic and antibacterial properties of the dual-functional composite. ► The notable potential application on blood contact device.