Lamellar crystalline self-assembly behaviour and solid lipid nanoparticles of a palmityl prodrug analogue of Capecitabine-A chemotherapy agent

► We have developed a novel amphiphile chemotherapy prodrug, 5-FCPal. ► 5-FCPal self-assembles into a non-swelling lamellar crystalline material. ► 5-FCPal can be formulated into colloidal solid lipid nanoparticles (SLNs). ► 5-FCPal SLNs displayed improved in vivo efficacy over a commercially available alternative.