کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
601267 879935 2011 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Enhancement of dissolution rate of mitotane and warfarin prepared by using microemulsion systems
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی شیمی کلوئیدی و سطحی
پیش نمایش صفحه اول مقاله
Enhancement of dissolution rate of mitotane and warfarin prepared by using microemulsion systems
چکیده انگلیسی

Micronization is the most effective way to enhance the dissolution rate of poorly water-soluble drugs and bioavailability in human body. Microemulsion systems were applied to micronize mitotane and warfarin by cooling method and solvent diffusion process. The triangle phase diagram of the ternary benzyl alcohol + sodium dodecyl sulfate (SDS) + water system was investigated at six different temperatures to determine an appropriate operational microemulsion regime for crystallization. The particle sizes of mitotane and warfarin re-crystallized from microemulsion systems were greatly reduced (to ∼1 μm) compared with that of the commercial ones. Consequently, the dissolution rate coefficients of re-crystallized mitotane and warfarin were significantly improved by, respectively, 7.5 and 13.3 times larger than that of the commercial ones. The crystal structures of re-crystallized mitotane and warfarin were the same as the commercial ones based on the XRD and DSC measurements. In addition, it is interesting to observe the variation of morphology of re-crystallized mitotane as a function of the composition of the SDS and the drug concentrations.

Figure optionsDownload as PowerPoint slideHighlights
► The triangle phase diagram of the ternary benzyl alcohol + sodium dodecyl sulfate + water system was investigated.
► The microemulsion systems were successfully applied to micronize mitotane and warfarin.
► The dissolution rate coefficients of micronized mitotane and warfarin were dramatically enhanced.
► The morphology of mitotane is subject to the SDS concentration in the microemulsion system.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Colloids and Surfaces B: Biointerfaces - Volume 85, Issue 2, 1 July 2011, Pages 366–372
نویسندگان
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