کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
601500 | 879945 | 2010 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Controlled release from directly compressible theophylline buccal tablets Controlled release from directly compressible theophylline buccal tablets](/preview/png/601500.png)
The aim of the current study was the development of theophylline buccal adhesive tablets using direct compression. Buccal adhesive formulations were developed using a water soluble resin with various combinations of mucoadhesive polymers. The prepared theophylline tablets were evaluated for tensile strength, swelling capacity and ex vivo mucoadhesion performance. Ex vivo mucoadhesion was assessed using porcine gingival tissue and the peak detachment forces were found to be suitable for a buccal adhesive tablet with a maximum of 1.5 N approximately. The effect of formulation composition on the release pattern was also investigated. Most formulations showed theophylline controlled release profiles depended on the grade and polymer ratio. The release mechanisms were found to fit Peppas’ kinetic model over a period of 5 h. In general the majority of the developed formulations presented suitable adhesion and controlled drug release.
Journal: Colloids and Surfaces B: Biointerfaces - Volume 77, Issue 2, 1 June 2010, Pages 227–233