کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6015243 1579907 2015 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Review articleOptogenetic tools for modulating and probing the epileptic network
ترجمه فارسی عنوان
بررسی ابزارهای آپوژنیتیک برای مدولاسیون و پروب های شبکه صرعی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
چکیده انگلیسی


- Optogenetics toolbox has already been shown to be somewhat effective at treating seizures in animal models of epilepsy.
- Outline the most recent advances in epilepsy research with optogenetic techniques.
- Discuss how this technology can contribute to our understanding and treatment of epilepsy in the future.

Epilepsy affects roughly 1% of the population worldwide. Although effective treatments with antiepileptic drugs are available, more than 20% of patients have seizures that are refractory to medical therapy and many patients experience adverse effects. Hence, there is a continued need for novel therapies for those patients. A new technique called “optogenetics” may offer a new hope for these refractory patients. Optogenetics is a technology based on the combination of optics and genetics, which can control or record neural activity with light. Following delivery of light-sensitive opsin genes such as channelrhodopsin-2 (ChR2), halorhodopsin (NpHR), and others into brain, excitation or inhibition of specific neurons in precise brain areas can be controlled by illumination at different wavelengths with very high temporal and spatial resolution. Neuromodulation with the optogenetics toolbox have already been shown to be effective at treating seizures in animal models of epilepsy. This review will outline the most recent advances in epilepsy research with optogenetic techniques and discuss how this technology can contribute to our understanding and treatment of epilepsy in the future.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Epilepsy Research - Volume 116, October 2015, Pages 15-26
نویسندگان
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