کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
601530 | 879947 | 2010 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Selective binding of small molecules to DNA: Application and perspectives
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
شیمی کلوئیدی و سطحی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Selective binding of small molecules to DNA: Application and perspectives Selective binding of small molecules to DNA: Application and perspectives](/preview/png/601530.png)
چکیده انگلیسی
More and more researchers are interested in DNA binders with sequence selectivity which may be developed to potential drugs. In this paper, we mainly review the compounds that selectively bind to special bases or sequences such as AT and GC-rich sequences. The selective binding of them to DNA sequences could affect the interactions of transcription factors with their target sequences in DNA. Furthermore, the design and effectiveness of sequence-selective DNA binding drugs are discussed. At last we put forward the some current challenges and solution in developing targeting anticancer drugs binding to specific oncogene.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Colloids and Surfaces B: Biointerfaces - Volume 79, Issue 1, 1 August 2010, Pages 1–4
Journal: Colloids and Surfaces B: Biointerfaces - Volume 79, Issue 1, 1 August 2010, Pages 1–4
نویسندگان
Bochu Wang, Jun Tan, Liancai Zhu,