کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6015393 1579909 2015 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Do Glut1 (glucose transporter type 1) defects exist in epilepsy patients responding to a ketogenic diet?
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Do Glut1 (glucose transporter type 1) defects exist in epilepsy patients responding to a ketogenic diet?
چکیده انگلیسی


- GLUT1 deficiency syndromes are known to respond to ketogenic diet.
- Ketogenic diet is an established treatment for pharmaco-resistant epilepsies.
- Sequencing of resistant patients responding well to a ketogenic diet.
- No GLUT1 mutation was found in the examined cohort.
- The Glut1 transporter seems not to be a relevant mechanism of ketogenic diet.

SummaryIn the recent years, several neurological syndromes related to defects of the glucose transporter type 1 (Glut1) have been descried. They include the glucose transporter deficiency syndrome (Glut1-DS) as the most severe form, the paroxysmal exertion-induced dyskinesia (PED), a form of spastic paraparesis (CSE) as well as the childhood (CAE) and the early-onset absence epilepsy (EOAE). Glut1, encoded by the gene SLC2A1, is the most relevant glucose transporter in the brain. All Glut1 syndromes respond well to a ketogenic diet (KD) and most of the patients show a rapid seizure control. Ketogenic Diet developed to an established treatment for other forms of pharmaco-resistant epilepsies. Since we were interested in the question if those patients might have an underlying Glut1 defect, we sequenced SLC2A1 in a cohort of 28 patients with different forms of pharmaco-resistant epilepsies responding well to a KD. Unfortunately, we could not detect any mutations in SLC2A1. The exact action mechanisms of KD in pharmaco-resistant epilepsy are not well understood, but bypassing the Glut1 transporter seems not to play an important role.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Epilepsy Research - Volume 114, August 2015, Pages 47-51
نویسندگان
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