Keywords: Newly diagnosed epilepsy; Antiepileptic drugs; Outcome patterns; Prognosis; Pharmacoresistance;
مقالات ISI (ترجمه نشده)
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Keywords: New antiepileptic drugs; Pharmacoresistance; Comparative effectiveness; All epilepsy/seizures;
Keywords: Antiepileptic drugs; Epilepsy; Clinical trials; Animal models; Pharmacoresistance; Precision medicine;
Keywords: AES; American Epilepsy Society; ASD; anti-seizure drug; ASP; Anticonvulsant Screening Program; BLA; basolateral amygdala; CC; convulsant current; CD; convulsive dose; BBB; blood-brain barrier; CNS; central nervous system; ED; effective dose; ETSP; Epileps
Keywords: Pilocarpine; TLE; Epilepsy; Status epilepticus; Two-hit; Pharmacoresistance;
Keywords: PTZ; pentylenetetrazole; SE; status epilepticus; SRS; spontaneous recurrent seizures; TLE; temporal lobe epilepsy; Diazepam; Phenobarbital; Scopolamine; Pharmacoresistance; Biomarkers;
Keywords: Drug development; Preclinical drug screening; Focal epilepsy; Non-convulsive seizure; Pharmacoresistance; Statistical power analysis
Keywords: Epilepsy; GABA receptors; Benzodiazepines; HPLC, high performance liquid chromatography; Pharmacoresistance; Kainate; BZD; benzodiazepine; EEG; electroencephalogram; SE; status epilepticus; SRS; spontaneous recurrent seizures;
Keywords: Drug resistance; Epilepsy surgery; Pharmacoeconomics; Pharmacoresistance; Reimbursement;
Keywords: Deep brain stimulation; Temporal lobe epilepsy; Hippocampal sclerosis; Pharmacoresistance; Outcome;
Flavonoid compounds as reversing agents of the P-glycoprotein-mediated multidrug resistance: An in vitro evaluation with focus on antiepileptic drugs
Keywords: Epilepsy; Flavonoids; In vitro studies; P-glycoprotein; Pharmacoresistance;
In vitro screening of dual flavonoid combinations for reversing P-glycoprotein-mediated multidrug resistance: Focus on antiepileptic drugs
Keywords: Epilepsy; Dual flavonoid combinations; Flavonoids; In vitro studies; P-glycoprotein; Pharmacoresistance; AEDs; Antiepileptic drugs; CBZ; Carbamazepine; CBZ-E; Carbamazepine-10,11-epoxide; CNS; Central nervous system; DMSO; dimethyl sulfoxide; DMEM; Dulbec
Do Glut1 (glucose transporter type 1) defects exist in epilepsy patients responding to a ketogenic diet?
Keywords: SLC2A1; Epilepsy; Pharmacoresistance; Antiepileptic drugs; Glut1 deficiency syndrome; Genetics;
Les critères prédictifs d'une épilepsie pharmacorésistante chez l'enfant
Keywords: Enfant; Ãpilepsie; Pharmacorésistance; Child; Epilepsy; Drug resistances;
Single versus combinatorial therapies in status epilepticus: Novel data from preclinical models
Keywords: ASD; antiseizure drug; EEG; electroencephalogram; NMDA; N-methyl-d-aspartate; RSE; refractory status epilepticus; SE; status epilepticus; SRSs; spontaneous recurrent seizures; Pharmacoresistance; Ketamine; Scopolamine; Acetylcholine; Neurodegeneration; Ep
The antiepileptic drug lamotrigine is a substrate of mouse and human breast cancer resistance protein (ABCG2)
Keywords: Epilepsy; Pharmacoresistance; Transporter hypothesis; P-glycoprotein; AED; antiepileptic drug; AUC; area under curve; BBB; blood-brain barrier; BCRP/Bcrp; breast cancer resistance protein; CETA; concentration equilibrium transport assay; MDCK; Madin-Dar
Inter-individual variation in the effect of antiepileptic drugs in the intrahippocampal kainate model of mesial temporal lobe epilepsy in mice
Keywords: Anti-seizure drugs; Refractory seizures; Pharmacoresistance; Hippocampus; AED; antiepileptic drug; ED; effective dose; EEG; electroencephalogram; HVWD; high-voltage sharp wave; HPD; hippocampal paroxysmal discharge; SE; status epilepticus; SLE; seizure-li
ABC transporter-driven pharmacoresistance in Amyotrophic Lateral Sclerosis
Keywords: Amyotrophic Lateral Sclerosis; Drug efflux transporters; Blood–brain barrier; Pharmacoresistance; Neurodegeneration
L'épilepsie associée aux tumeurs cérébrales
Keywords: Ãpilepsie; Gliome; Médicament antiépileptique; Pharmaco-résistance; Epilepsy; Glioma; Antiepileptic drug; Pharmacoresistance;
ReviewRegulation of ABC efflux transporters at blood-brain barrier in health and neurological disorders
Keywords: ABC efflux transporters; Blood-brain barrier; Neuroprotection; Pharmacoresistance;
Pharmacogenomics of intrinsic and acquired pharmacoresistance in colorectal cancer: Toward targeted personalized therapy
Keywords: Pharmacoresistance; Colorectal cancer; Polymorphism; Somatic mutation; Pharmacogenetic
(R)-[11C]PK11195 brain uptake as a biomarker of inflammation and antiepileptic drug resistance: Evaluation in a rat epilepsy model
Keywords: Positron emission tomography; Translocator protein 18Â kDa; (R)-[11C]PK11195; Neuroinflammation; Pharmacoresistance; Drug refractoriness; TSPO; translocator protein 18Â kDa; PET; positron emission tomography; TLE; temporal lobe epilepsy; AED; antiepilepti
Low potency and limited efficacy of antiepileptic drugs in the mouse 6Â Hz corneal kindling model
Keywords: Hz; hertz; EEG; electroencephalogram; mA; milliampere; ms; millisecond; i.p.; intraperitoneal; Kindling; Seizures; Epilepsy; Levetiracetam; 6Â Hz; Pharmacoresistance;
Management of Refractory Epilepsy
Keywords: seizures; pharmacoresistance; antiepileptic drug; alternative therapy; vagal nerve stimulation; diet
Effects of EPHX1, SCN1A and CYP3A4 genetic polymorphisms on plasma carbamazepine concentrations and pharmacoresistance in Chinese patients with epilepsy
Keywords: Epilepsy; Carbamazepine; Polymorphism; Pharmacoresistance; Plasma concentration
Epilepsy and brain inflammation
Keywords: Glia; Leukocytes; Seizures; Blood–brain barrier; Experimental models of epilepsy; Pharmacoresistance
Selective increase of two ABC drug efflux transporters at the blood–spinal cord barrier suggests induced pharmacoresistance in ALS
Keywords: Amyotrophic Lateral Sclerosis; ABC transporters; P-glycoprotein; Breast cancer resistance protein; Blood–brain barrier; Blood–spinal cord barrier; Pharmacoresistance
The multidrug transporter P-glycoprotein in pharmacoresistance to antiepileptic drugs
Keywords: P-glycoprotein; multidrug transporter; pharmacoresistance; antiepileptic drugs
Role of CNS efflux drug transporters in antiepileptic drug delivery: Overcoming CNS efflux drug transport
Keywords: Pharmacoresistance; Blood–brain barrier; Multidrug transporter; Cyclooxygenase-2; Epilepsy; NMDA receptor
Effects of ABCB1 polymorphisms on plasma carbamazepine concentrations and pharmacoresistance in Chinese patients with epilepsy
Keywords: Epilepsy; Carbamazepine; Polymorphism; Pharmacoresistance; Pharmacogenomics
Functional test of multidrug transporter activity in hippocampal–neocortical brain slices from epileptic patients
Keywords: P-glycoprotein; Multidrug transporters; Multidrug resistance associated protein; Pharmacoresistance; Temporal lobe epilepsy; Brain slice; Calcein
Impact of seizure activity on free extracellular phenytoin concentrations in amygdala-kindled rats
Keywords: Epilepsy; Status epilepticus; Antiepileptic drugs; Phenytoin; Blood–brain barrier; Pharmacoresistance
Verapamil attenuates the malignant treatment course in recurrent status epilepticus
Keywords: Malignant; Multidrug transporter; Pharmacoresistance; P-glycoprotein; Refractory; Recurrent; Status epilepticus; Verapamil
Antiepileptic drug therapy the story so far
Keywords: Antiepileptic drugs; Mechanism of action; Epilepsy; Pharmacoresistance; Prognosis
ABCB1 C3435T polymorphism and the risk of resistance to antiepileptic drugs in epilepsy: A systematic review and meta-analysis
Keywords: Meta-analysis; Epilepsy; ABCB1; Polymorphism; P-glycoprotein; Antiepileptic drugs; Pharmacoresistance
Cox-2 inhibition can lead to adverse effects in a rat model for temporal lobe epilepsy
Keywords: Status epilepticus; Neuroinflammation; Temporal lobe epilepsy; P-glycoprotein; Pharmacoresistance
Exposure to antiepileptic drugs does not alter the functionality of P-glycoprotein in brain capillary endothelial and kidney cell lines
Keywords: Phenobarbital; Nuclear receptor; PXR; CAR; Pharmacoresistance; Epilepsy
Targeting regulation of ABC efflux transporters in brain diseases: A novel therapeutic approach
Keywords: Pharmacoresistance; Blood–brain barrier; Multidrug transporter; P-glycoprotein; EpilepsyABC, ATP-binding cassette; AIDS, acquired immunodeficiency syndrome; BBB, blood–brain barrier; CNS, central nervous system; COX, cyclooxygenase; HIV, human immunodefic
Evaluation of transport of common antiepileptic drugs by human multidrug resistance-associated proteins (MRP1, 2 and 5) that are overexpressed in pharmacoresistant epilepsy
Keywords: Multidrug transporters; Blood-brain barrier; Epilepsy; Pharmacoresistance;
ECoG studies of valproate, carbamazepine and halothane in frontal-lobe epilepsy induced by head injury in the rat
Keywords: AED; anti-epileptic drug; VPA; valproaic acid; CBZ; carbamazepine; CSRSs; chronic spontaneous recurrent seizures; CPS; complex partial seizure; TD50; dose producing toxicity in 50% of subjects; Posttraumatic epilepsy; Neocortical epilepsy; Trauma; Screeni
In vivo down-regulation of mouse brain capillary P-glycoprotein: A preliminary investigation
Keywords: P-glycoprotein; Multidrug transporter; Blood–brain barrier; Pharmacoresistance; siRNA; Epilepsy
Risk factors for valproic acid resistance in childhood absence epilepsy
Keywords: Co-morbidity; Anticonvulsants; Refractory seizures; Pharmacoresistance
Prevention of seizure-induced up-regulation of endothelial P-glycoprotein by COX-2 inhibition
Keywords: Epilepsy; Status epilepticus; P-glycoprotein; Pharmacoresistance; Multidrug transporter; Cyclooxygenase-2
Over-expression of P-glycoprotein in the canine brain following spontaneous status epilepticus
Keywords: Pharmacoresistance; Drug-refractoriness; P-glycoprotein; Multidrug transporter; Efflux transporter; Blood-brain barrier;
The national temporal lobectomy survey
Keywords: Epilepsy; Temporal lobectomy; Pharmacoresistance; Antiepileptic drugs; Preoperative counseling; Informed consent; Wada test
La pharmacorésistance des épilepsies partielles : épidémiologie, mécanismes, pharmacogénétique, perspectives thérapeutiques
Keywords: Epilepsy; Drug resistance; Multidrug transporters; Ãpilepsie; Pharmacorésistance; Transporteurs de médicaments multiples;
Nordihydroguaiaretic acid increases glutamate uptake in vitro and in vivo: Therapeutic implications for amyotrophic lateral sclerosis
Keywords: Amyotrophic lateral sclerosis; Glutamate transporter; Excitotoxicity; Pharmacoresistance; Nordihydroguaiaretic acid; Neurodegeneration; Arachidonic acid; P-glycoprotein; Neuroinflammation; SOD1
Glutamate is critically involved in seizure-induced overexpression of P-glycoprotein in the brain
Keywords: Epilepsy; Pharmacoresistance; Pilocarpine; MK-801; Tariquidar; Antiepileptic drugs
Antiepileptic drug resistant rats differ from drug responsive rats in GABAA receptor subunit expression in a model of temporal lobe epilepsy
Keywords: GABA; Phenobarbital; Pharmacoresistance; Hippocampus; Dentate gyrus
Verbal cognition and attention deficits do not explain the verbal memory decline associated with pharmacoresistant partial epilepsy
Keywords: Pharmacoresistance; Partial epilepsy; Longitudinal; Change; Verbal memory; Verbal cognition; Attention