کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3087526 | 1190150 | 2015 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Les critères prédictifs d'une épilepsie pharmacorésistante chez l'enfant
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
عصب شناسی
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چکیده انگلیسی
The aim of this study is to identify early predictors of refractory epilepsy. From 600Â epileptic children followed for at least 2Â years in the department of neurology of Charles Nicolle hospital of Tunis, were identified children with refractory epilepsy. Controls were children who responded well to antiepileptic drugs and who were seizure free for at least 2Â years. We collected anamnestic, clinical, neuropsychological and radiological data for all children. We identified 67Â children with refractory epilepsy, representing 11.6% of the initial population. At diagnosis, the average age was 9.16Â years. Some factors have been identified as predictors of drug resistance epilepsy: age of onset less than one year, partial and atonic seizure, combination of several types of attacks, presence of mental retardation and pyramidal syndrome, abnormal electroencephalogram especially focal abnormalities, spike, amplitude abnormalities, interhemispheric asymmetry; and resistance to first antiepileptic drug. Symptomatic epilepsy, especially if associated with radiological lesions such as hippocampal sclerosis and structural brain malformations, was highly correlated with drug resistance. Our study suggests that the initial presentation of epilepsy could predict long-term outcome to drug resistance epilepsy if a detailed analysis of anamnestic, clinical and complementary data is established.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Revue Neurologique - Volume 171, Issue 10, October 2015, Pages 730-735
Journal: Revue Neurologique - Volume 171, Issue 10, October 2015, Pages 730-735
نویسندگان
S. Fray, N. Ben Ali, M. Kchaou, S. Chebbi, S. Belal,