کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6015399 | 1579910 | 2015 | 6 صفحه PDF | دانلود رایگان |
- In people with epilepsy, AED non-adherence is present in nearly 40% of admissions for status epilepticus (SE).
- The history-based information on recent adherence is often elusive in SE.
- The prognosis of SE due to non-adherence is usually good.
- This is the first study to demonstrate the extent of non-adherence in SE.
SummaryPurposeTo investigate the role of non-adherence to antiepileptic drug treatment as a trigger for status epilepticus (SE).Methods124 consecutive admissions for SE in patients with established epilepsy were studied. Those who had had therapeutic drug monitoring at admission were identified. Non-adherence was defined as a serum concentration/dose ratio at admission of <75% of the patient's own trough control value.ResultsIn 64 cases serum concentration/dose ratios at admission were available for comparison with morning trough values. Treatment non-adherence was identified in a total of 24 (38%), 50% in children, 32% in patients 16-59 years and in 44% above 60. Missed medication had been reported in only two of these patients. No cases with confirmed non-adherence had a fatal outcome (p = 0.05). No significant differences between non-adherent and adherent admissions concerning demographic factors or epilepsy and SE characteristics were found.ConclusionAntiepileptic drug non-adherence is a common cause of SE across all ages, but is not always identified due to the first history-based information often being elusive. Prompt and reliable recognition of non-adherence is imperative for correct management. This is the first study to demonstrate the extent of non-adherence by therapeutic drug monitoring in SE.
Journal: Epilepsy Research - Volume 113, July 2015, Pages 28-33