کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6015399 1579910 2015 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Treatment non-adherence as a trigger for status epilepticus: An observational, retrospective study based on therapeutic drug monitoring
ترجمه فارسی عنوان
عدم پذیرش درمان به عنوان یک عامل برای وضعیت صرع: یک مطالعه گذشته نگر، مبتنی بر نظارت بر دارو
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
چکیده انگلیسی


- In people with epilepsy, AED non-adherence is present in nearly 40% of admissions for status epilepticus (SE).
- The history-based information on recent adherence is often elusive in SE.
- The prognosis of SE due to non-adherence is usually good.
- This is the first study to demonstrate the extent of non-adherence in SE.

SummaryPurposeTo investigate the role of non-adherence to antiepileptic drug treatment as a trigger for status epilepticus (SE).Methods124 consecutive admissions for SE in patients with established epilepsy were studied. Those who had had therapeutic drug monitoring at admission were identified. Non-adherence was defined as a serum concentration/dose ratio at admission of <75% of the patient's own trough control value.ResultsIn 64 cases serum concentration/dose ratios at admission were available for comparison with morning trough values. Treatment non-adherence was identified in a total of 24 (38%), 50% in children, 32% in patients 16-59 years and in 44% above 60. Missed medication had been reported in only two of these patients. No cases with confirmed non-adherence had a fatal outcome (p = 0.05). No significant differences between non-adherent and adherent admissions concerning demographic factors or epilepsy and SE characteristics were found.ConclusionAntiepileptic drug non-adherence is a common cause of SE across all ages, but is not always identified due to the first history-based information often being elusive. Prompt and reliable recognition of non-adherence is imperative for correct management. This is the first study to demonstrate the extent of non-adherence by therapeutic drug monitoring in SE.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Epilepsy Research - Volume 113, July 2015, Pages 28-33
نویسندگان
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