کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
601853 879955 2009 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Patterning of biomolecules on a poly(ɛ-caprolactone) film surface functionalized by ion implantation
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی شیمی کلوئیدی و سطحی
پیش نمایش صفحه اول مقاله
Patterning of biomolecules on a poly(ɛ-caprolactone) film surface functionalized by ion implantation
چکیده انگلیسی

Biomolecule patterning is important due to its potential applications in biodevices, tissue engineering, and drug delivery. In this study, we developed a new method for a biomolecular patterning on poly(ɛ-caprolactone) (PCL) films based on ion implantation. Ion implantation on a PCL film surface resulted in the formation of carboxylic acid groups. The generated carboxylic acid groups were used for the covalent immobilization of amine-functionalized p-DNA, followed by hybridization with fluorescently tagged c-DNA. Biotin-amine was also covalently immobilized on the carboxylic acid generated PCL surfaces. Successful biotin-specific binding of streptavidin further confirmed the potential of this strategy for patterning of various biomolecules.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Colloids and Surfaces B: Biointerfaces - Volume 74, Issue 1, 1 November 2009, Pages 375–379
نویسندگان
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