کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6020051 | 1580388 | 2015 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Circulating brain derived neurotrophic factor (BDNF) and frequency of BDNF positive T cells in peripheral blood in human ischemic stroke: Effect on outcome
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کلمات کلیدی
FOXP3Protective immunity - ایمنی محافظRegulatory T cells - سلولهای تی تنظیمکنندهacute ischemic stroke - سکته مغزی ایسکمیک حادbrain derived neurotrophic factor - عامل مغز استخوان مغز استخوان استFlow cytometry - فلوسیتومتریNeuroprotection - محافظت نورونی یا محافظت از عصبStroke outcome - نتیجه سکته مغزی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Circulating brain derived neurotrophic factor (BDNF) and frequency of BDNF positive T cells in peripheral blood in human ischemic stroke: Effect on outcome Circulating brain derived neurotrophic factor (BDNF) and frequency of BDNF positive T cells in peripheral blood in human ischemic stroke: Effect on outcome](/preview/png/6020051.png)
چکیده انگلیسی
The aim of this study was to measure the levels of circulating BDNF and the frequency of BDNF-producing T cells after acute ischaemic stroke. Serum BDNF levels were measured by ELISA. Flow cytometry was used to enumerate peripheral blood leukocytes that were labelled with antibodies against markers of T cells, T regulatory cells (Tregs), and intracellular BDNF. There was a slight increase in serum BDNF levels after stroke. There was no overall difference between stroke patients and controls in the frequency of CD4+ and CD8+ BDNF+ cells, although a subgroup of stroke patients showed high frequencies of these cells. However, there was an increase in the percentage of BDNF+ Treg cells in the CD4+ population in stroke patients compared to controls. Patients with high percentages of CD4+ BDNF+ Treg cells had a better outcome at 6Â months than those with lower levels. These groups did not differ in age, gender or initial stroke severity. Enhancement of BDNF production after stroke could be a useful means of improving neuroprotection and recovery after stroke.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 286, 15 September 2015, Pages 42-47
Journal: Journal of Neuroimmunology - Volume 286, 15 September 2015, Pages 42-47
نویسندگان
Adeline Chan, Jun Yan, Peter Csurhes, Judith Greer, Pamela McCombe,