کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6020170 1580389 2015 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Robust increase of microglia proliferation in the fornix of hippocampal axonal pathway after a single LPS stimulation
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Robust increase of microglia proliferation in the fornix of hippocampal axonal pathway after a single LPS stimulation
چکیده انگلیسی


- A single LPS treatment induced robust proliferation of microglia in the fornix.
- Consecutive administration of LPS did not increase microglial proliferation.
- VEGF signaling inhibitor suppressed LPS-induced increase of microglia proliferation.

Microglia are resident immunocompetent cells having important roles in innate immunity in the brains. In the present study, we found that a single lipopolysaccharide (LPS) administration significantly increased microglial proliferation in the fornix and dentate gyrus (DG) but not the cerebral cortex and corpus callosum of adult mice. LPS-induced microglial proliferation was especially robust at the white matter of the fornix. The density of microglia increased in the fornix and DG for roughly one week and returned to basal levels at least 20 days after a single LPS administration. Consecutive LPS administration did not induce such dramatic increase of microglial proliferation in the fornix. The inhibition of vascular endothelial growth factor signaling by AZD2171 largely suppressed LPS-induced increase of microglial proliferation in the fornix. In conclusion, the present study indicates that the hippocampal neuronal system has a higher proliferative microglial capability against LPS-induced inflammatory administration compared with other brain regions.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 285, 15 August 2015, Pages 31-40
نویسندگان
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