کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6020222 | 1580394 | 2015 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Vitamin D status and effect of interferon-β1a treatment on MRI activity and serum inflammation markers in relapsing-remitting multiple sclerosis
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
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چکیده انگلیسی
To explore if vitamin D modulates interferon-β1a treatment effects in relapsing-remitting multiple sclerosis, we examined relationships between serum vitamin D and magnetic resonance imaging (MRI) activity and ten systemic inflammation markers in 88 patients, before and during treatment. Odds ratios for all MRI parameters were negatively associated with vitamin D levels before therapy, but converged to equally low values irrespective of vitamin D status during treatment. During therapy, similar alterations of MRI activity and inflammation markers were found across patients categorized by mean vitamin D values. This suggests that vitamin D status has no major influence on interferon-β1a treatment effects.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 280, 15 March 2015, Pages 21-28
Journal: Journal of Neuroimmunology - Volume 280, 15 March 2015, Pages 21-28
نویسندگان
Egil Røsjø, Kjell-Morten Myhr, Kristin I. Løken-Amsrud, Søren J. Bakke, Antonie G. Beiske, Kristian S. Bjerve, Harald Hovdal, Finn LilleÃ¥s, Rune Midgard, Tom Pedersen, JÅ«ratÄ Å altytÄ Benth, Ãivind Torkildsen, Stig Wergeland,